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KMID : 0359320000400010166
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Korean Journal of Veterinary Research
2000 Volume.40 No. 1 p.166 ~ p.172
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Antitumor effects of recombinant human interferon a-2ａ and hydroxyurea against chronic myelogenous leukemia
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Abstract
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Prior to a clinical trial, the in vitro and in vivo antitumor effects of a new recombinant human interferon α-2a (rHu/IFN α-2a) with/without hydroxyurea (HU) were investigated using chronic myelogenous leukemia (CML)-derived cell lines (K562 and KU812F) and BALB/c nude. mice transplanted with KU812F cells. The rHu/IFN α-2a (10⁴-l0^6IU/㎖) strongly inhibited proliferation of both cell lines and the combined treatments with HU (10㎍/㎖) were more effective. In nude mice transplanted with KU812F cells. rHu/IFN α-2a(1×10^6IU) inhibited tumor growth by 42-65% at 15-21 days post-transplantation (DPT). The combined treatment of rHu/IFN α-2a (5×10^5IU) with HU (0.25㎎/g b.w.) inhibited the tumor growth by 48-67% at 12-21 DPT. In addition, the treatment of rHu/IFN α-2a (5×10^6IU or 1×10^7 IU) rejected tumor transplantation by 40%. These results suggest that the new rHU/IFN α-2a alone or with HU is effective on CML cell lines.
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KEYWORD
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